From Wegovy to Mounjaro: What to Expect When Making the Switch?

Thinking of switching from Wegovy to Mounjaro? Transitioning from Wegovy (semaglutide) to Mounjaro (tirzepatide) means moving from a GLP-1 agonist to a dual GIP/GLP-1 agonist. Mounjaro may offer more effective results, but starting at a lower dose (typically 2.5mg) helps your body adjust, even after the highest 2.4mg dose of Wegovy.

Always make the switch under medical supervision for safety. Expect temporary changes in appetite control as you adjust, but generally no severe withdrawal symptoms. This switch, though promising, should always be done under medical supervision after a 7-day waiting period post-Wegovy to ensure safety and effectiveness.

Switching Smart: Key Takeaways from Wegovy to Mounjaro

• Medical supervision is essential when switching from Wegovy to Mounjaro, with a required 7-day gap between treatments.
• Mounjaro’s dual-hormone action (GLP-1 + GIP) may deliver greater and more consistent weight loss than Wegovy for some individuals.
• Lower starting doses matter, even for those previously on higher Wegovy doses, to reduce side-effect risk.
• Switching is often considered when weight loss plateaus or side effects persist on Wegovy.
• Eligibility and safety checks remain crucial, including age, medical history, pregnancy status, and medication interactions.
• Long-term success depends on guidance, dose adjustments, and adherence to MHRA-aligned clinical advice.

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Why People Switch from Wegovy to Mounjaro

Wegovy (Semaglutide) helps with weight loss by reducing appetite and slowing digestion, but some individuals may experience a plateau or side effects like nausea and fatigue. If these issues persist, switching to the weight loss injection Mounjaro (Tirzepatide) may be an option worth considering.

Mounjaro (Tirzepatide) is a dual agonist, targeting both GLP-1 and GIP hormones, unlike Wegovy, which only targets GLP-1. The addition of GIP helps with insulin regulation and hunger control, leading to greater weight loss, often more than 20%. Always consult with a healthcare professional before switching to ensure it’s the right choice for you.

What are the benefits of switching from Wegovy to Mounjaro?

If you’re not seeing the results expected with Wegovy or experiencing side effects, you may consider switching to the weight loss injection Mounjaro. It contains tirzepatide, which may be better tolerated than semaglutide in Wegovy.

Studies show Mounjaro can lead to up to 22.5% weight loss over 72 weeks at the highest dose, compared to 15 to 17% with Wegovy over 68 weeks. It works by mimicking both GLP-1 and GIP hormones, enhancing weight loss benefits. This dual-action mechanism may offer more effective results for some individuals.

Always consult a healthcare provider before making the switch to ensure it’s right for you.

What to Consider Before Switching from Wegovy to Mounjaro

You may consider switching from Wegovy to Mounjaro if you meet the eligibility criteria for both medications.

To be eligible for Mounjaro, you should:

• Be over 18 years old
• Have no medical conditions or allergies that would make weight loss injections unsuitable, such as an allergy to the active ingredients
• Not be pregnant or breastfeeding
• Not be taking any medication that could interact negatively with the weight loss injections, leading to severe side effects

Even if you’ve reached a BMI of 25 or lower, switching may still be an option, but it is essential to consult with your healthcare provider to ensure Mounjaro is suitable for your needs. Always follow professional advice before making any changes.

How to Switch from Wegovy to Mounjaro: A Step-by-Step Guide

It’s essential to follow professional medical advice to ensure a safe and effective transition between medications. Always make sure your treatment plan is tailored to your health needs and carried out under expert supervision.

Consult Your Doctor: Before switching, always discuss the change with your healthcare provider to ensure it’s right for you.

Stop Taking Wegovy: Once your last pen is finished, stop taking Wegovy. If you’re switching due to side effects, you can stop immediately.

Wait 7 Days: After stopping Wegovy, wait 7 days before starting Mounjaro. This allows time for Wegovy to leave your system.

Start Mounjaro at the Correct Dose:

• If you were on 1mg or less of Wegovy, begin with 2.5mg of Mounjaro.
• If you were on 1.7mg or 2.4mg of Wegovy, start with 5mg of Mounjaro.

Consider Side Effects: If you’ve experienced side effects from Wegovy, your doctor may recommend starting with the lower 2.5mg dose of Mounjaro to minimise risks.

Adjust Dosage If Needed: If you’re satisfied with your weight loss results and aren’t experiencing severe side effects, you can continue with the prescribed dose or switch to a lower maintenance dose.

Switching medications is a significant decision. Mayfair Weight Loss Clinic is here to guide you through the process and ensure the best approach for your weight loss journey.

Final Thoughts: Switching from Wegovy to Mounjaro

Switching from Wegovy to Mounjaro may offer a more effective weight loss option, especially for those who haven’t seen the desired results or are facing side effects with Wegovy. It works through a dual-action mechanism, targeting both GLP-1 and GIP hormones, which can lead to more significant weight loss.

It’s crucial to consult with your healthcare provider and follow MHRA guidelines to ensure the switch is appropriate for your specific health needs. Always make this decision with professional medical guidance to ensure it’s the right choice for you.

Frequently Asked Questions

Can I switch from Wegovy to Mounjaro immediately?

No, a 7-day waiting period is required after your last dose of Wegovy before starting Mounjaro to allow sufficient time for Wegovy to leave your system.

How do I know if switching to Mounjaro is right for me?

You should consult your healthcare provider to assess whether Mounjaro is suitable for your needs, particularly if you’ve experienced side effects or insufficient results with Wegovy.

What is the main difference between Wegovy and Mounjaro?

While both medications are designed to help with weight loss, Mounjaro is a dual agonist that targets both GLP-1 and GIP hormones, offering potentially more effective weight loss compared to Wegovy, which only targets GLP-1.

What kind of weight loss can I expect from Mounjaro?

Studies show that Mounjaro can result in up to 22.5% weight loss over 72 weeks at the highest dose, compared to 15-17% with Wegovy over 68 weeks.

Can I start Mounjaro at a higher dose if I was on a high dose of Wegovy?

No, Mounjaro should be started at a lower dose, even if you were on the highest dose of Wegovy. Your doctor will determine the appropriate starting dose.

What are the side effects of Mounjaro compared to Wegovy?

Mounjaro may be better tolerated than Wegovy, but like all medications, it may still cause side effects. Discuss potential side effects with your healthcare provider before switching.

Am I eligible to switch to Mounjaro?

You must be over 18, have no allergies to the medication, and not be pregnant or breastfeeding. Your healthcare provider will evaluate if you meet the criteria and if Mounjaro is suitable for your specific needs.

What should I do if I experience side effects while on Mounjaro?

If you experience severe side effects, consult your doctor immediately. Your doctor may adjust your dose or recommend an alternative treatment plan based on your experience.